N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide

Base Information

Chemical Name:N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide
CAS No.:1609107-86-9
Molecular Formula:C₄₉H₆₆N₈O₁₀
Molecular Weight:927.111
Hs Code.:

N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide

Synonyms:N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide

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Chemical Property of N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide

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Technology Process of N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide

There total 4 articles about N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1438853-36-1
4-[(N-5-carbamoyl-N-2-{(3S)-3-[(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)amino]-4-methylpent-1-en-2-yl}-L-ornithyl)amino]benzyl 4-nitrophenyl carbonate

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1609107-86-9
N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h;

Reference yield:

: 88574-06-5
6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid

: 1609107-86-9
N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 15 h

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; dmap / N,N-dimethyl-formamide / 0.5 h

With dmap; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 159857-79-1
(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-N-[4-(hydroxymethyl)phenyl]-5-ureidopentanamide

: 1609107-86-9
N-(6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoyl)-L-valyl-N-{4-[({[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl}oxy)methyl]phenyl}-N-5-carbamoyl-L-ornithinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 15 h

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; dmap / N,N-dimethyl-formamide / 0.5 h

With dmap; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;