2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

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Chemical Name:2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide
CAS No.:1046861-65-7
Molecular Formula:C₁₀H₁₂IN₅O
Molecular Weight:345.143
Hs Code.:

Synonyms:2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

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Chemical Property of 2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

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Technology Process of 2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

There total 1 articles about 2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1033090-34-4
N-cyclopropyl-1H-imidazole-1-carboxamide

: 1207961-45-2
4-iodo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine hydrogen iodide salt

: 1046861-65-7
2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 65 ℃; for 2h;

Reference yield: 97.0%

: 1028332-22-0
(2,4-dichloro-6-hydroxyphenyl)boronic acid

: 1046861-65-7
2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

: 1046861-31-7
2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1028332-22-0
(2,4-dichloro-6-hydroxyphenyl)boronic acid

: 1046861-65-7
2-amino-4-iodo-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

: 1303415-67-9
2-amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 8 h / 85 °C / Inert atmosphere

2: caesium carbonate / dimethyl sulfoxide / 4 h / 65 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; In 1,4-dioxane; dimethyl sulfoxide; 1: Suzuki coupling;
DOI:10.1021/jm200128m