2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid

Base Information

Chemical Name:2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid
CAS No.:105852-42-4
Molecular Formula:C₂₆H₃₉NO₅
Molecular Weight:445.599
Hs Code.:

Synonyms:2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid

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Chemical Property of 2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid

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Technology Process of 2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid

There total 8 articles about 2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: methyl 2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-2(R,S)-butyrate

: 105852-88-8
2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2R)-butyric acid

: 105852-42-4
2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid

Guidance literature:: With potassium tert-butylate; water; In diethyl ether; for 18h; Ambient temperature;
DOI:10.1021/jm00117a027

Reference yield:

: 503-74-2
3-methylbutyric acid

: hexamethylphosphoramide (HMPA)

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

: 105852-42-4,105864-88-8,130227-93-9
(2RS)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-3-methylbutanoic acid

Guidance literature:: With n-butyllithium; ammonium chloride; diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

: 556-24-1
methyl 3-methylbutanoate

: 105852-42-4
2-<<3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-(4S)-1,3-oxazolidin-5-yl>methyl>-3-methyl-(2S)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / diisopropylamine, n-butyllitium / tetrahydrofuran; hexamethylphosphoric acid triamide / 2.5 h / Ambient temperature

2: 42 percent / potassium tert-butoxide, H₂O / diethyl ether / 18 h / Ambient temperature

With n-butyllithium; potassium tert-butylate; water; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1021/jm00117a027