(S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate

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Chemical Name:(S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate
CAS No.:1401468-85-6
Molecular Formula:C₃₇H₄₆BrN₃O₈
Molecular Weight:740.692
Hs Code.:

Synonyms:(S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate

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Chemical Property of (S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate

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Technology Process of (S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate

There total 1 articles about (S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1364375-66-5
4-bromo-3,5-diiodopyridine

: 119768-48-8
(S)-2-((tert-butoxycarbonyl)amino)-4-iodobutyric acid benzyl ester

: 1401468-85-6
(S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate

Guidance literature:: (S)-2-N-tert-butoxycarbonylamino-4-iodo-butanoic acid benzyl ester; With chloro-trimethyl-silane; zinc; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere; Molecular sieve;

4-bromo-3,5-diiodopyridine; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; In N,N-dimethyl-formamide; at 50 ℃; for 5h; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tetlet.2012.08.084

Reference yield: 56.0%

: 1401468-85-6
(S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate

: 1422507-41-2
(2S,2’S)-benzyl 4,4’-(pyridine-3,5-diyl)bis(2-(tert-butoxycarbonylamino)butanoate)

Guidance literature:: With chloro-trimethyl-silane; zinc; In N,N-dimethyl-formamide; at 50 ℃; for 24h; Inert atmosphere;
DOI:10.3987/COM-12-12600

Reference yield:

: 1401468-85-6
(S)-benzyl 4-(5-((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-bromopyridin-3-yl)-2-(tert-butoxycarbonylamino)butanoate

: 3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-1-((S)-6-(benzyloxy)-5-(tertbutoxycarbonylamino)-6-oxohexyl)pyridinium iodide

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; chloro-trimethyl-silane / N,N-dimethyl-formamide / 24 h / 50 °C / Inert atmosphere

2: nitromethane / 24 h / 80 °C / Inert atmosphere

With chloro-trimethyl-silane; zinc; In nitromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-12-12600