tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate

Base Information

Chemical Name:tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate
CAS No.:911313-15-0
Molecular Formula:C₂₆H₃₂ClN₃O₃
Molecular Weight:470.011
Hs Code.:

Synonyms:tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate

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Chemical Property of tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate

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Technology Process of tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate

There total 3 articles about tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911313-12-7
(R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate

: 911313-15-0
tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 60h;

Reference yield:

: 192513-60-3
2-chloro-(4-pyrrolidin-1-yl) benzoic acid

: 911313-15-0
tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

2: triethylamine / dichloromethane / 66 h / 0 - 20 °C

3: potassium carbonate / ethanol / 1 h / Heating / reflux

4: sodium tetrahydroborate; ethanol / 20 °C / Heating / reflux

5: dichloromethane / 21 h / 20 °C

6: triethylamine / tetrahydrofuran / 1.25 h / 0 - 45 °C

7: sodium hydride / tetrahydrofuran / 60 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; ethanol; sodium hydride; potassium carbonate; triethylamine; 1-methyl-pyrrolidin-2-one; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 911312-93-1
2-chloro-4-pyrrolidin-1-ylbenzoyl chloride

: 911313-15-0
tert-butyl (R)-1-(2-chloro-4-pyrrolidin-1-ylbenzoyl)-3-methyl-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepin-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 66 h / 0 - 20 °C

2: potassium carbonate / ethanol / 1 h / Heating / reflux

3: sodium tetrahydroborate; ethanol / 20 °C / Heating / reflux

4: dichloromethane / 21 h / 20 °C

5: triethylamine / tetrahydrofuran / 1.25 h / 0 - 45 °C

6: sodium hydride / tetrahydrofuran / 60 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;