(R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate

Base Information

Chemical Name:(R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate
CAS No.:911313-12-7
Molecular Formula:C₂₇H₃₆ClN₃O₆S
Molecular Weight:566.118
Hs Code.:

Synonyms:(R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate

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Chemical Property of (R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate

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Technology Process of (R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate

There total 3 articles about (R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911313-03-6
tert-Butyl 2-(2-chloro-4-pyrrolidin-1-ylbenzoylamino)benzyl-((R)-2-hydroxy-1-methylethyl)carbamate

: 124-63-0
methanesulfonyl chloride

: 911313-12-7
(R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 45 ℃; for 1.25h;

Reference yield:

: 192513-60-3
2-chloro-(4-pyrrolidin-1-yl) benzoic acid

: 911313-12-7
(R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

2: triethylamine / dichloromethane / 66 h / 0 - 20 °C

3: potassium carbonate / ethanol / 1 h / Heating / reflux

4: sodium tetrahydroborate; ethanol / 20 °C / Heating / reflux

5: dichloromethane / 21 h / 20 °C

6: triethylamine / tetrahydrofuran / 1.25 h / 0 - 45 °C

With sodium tetrahydroborate; thionyl chloride; ethanol; potassium carbonate; triethylamine; 1-methyl-pyrrolidin-2-one; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 911312-93-1
2-chloro-4-pyrrolidin-1-ylbenzoyl chloride

: 911313-12-7
(R)-2-{tert-Butoxycarbonyl[2-(2-chloro-4-pyrrolidin-1-yl-benzoylamino)benzyl]amino}propyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 66 h / 0 - 20 °C

2: potassium carbonate / ethanol / 1 h / Heating / reflux

3: sodium tetrahydroborate; ethanol / 20 °C / Heating / reflux

4: dichloromethane / 21 h / 20 °C

5: triethylamine / tetrahydrofuran / 1.25 h / 0 - 45 °C

With sodium tetrahydroborate; ethanol; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;