C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂

Base Information

Chemical Name:C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂
CAS No.:694491-81-1
Molecular Formula:C₅₈H₆₈N₆O₁₂
Molecular Weight:1041.21
Hs Code.:

C<sub>49</sub>H<sub>59</sub>N<sub>6</sub>O<sub>10</sub>C<sub>8</sub>H<sub>7</sub>O<sub>2</sub>CH<sub>2</sub>

Synonyms:C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂

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Chemical Property of C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂

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Technology Process of C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂

There total 6 articles about C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 304466-90-8
(9S,12S)-12-(tert-Butoxycarbonyl-methyl-amino)-4-methoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid benzyl ester

: 694491-80-0
(S)-2-[(S)-2-{[(S)-2-((R)-2-Benzyloxycarbonylamino-pentanoylamino)-propionyl]-methyl-amino}-3-(4-methoxy-phenyl)-propionylamino]-propionic acid

: 694491-81-1
C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂

Guidance literature:: (9S,12S)-12-(tert-Butoxycarbonyl-methyl-amino)-4-methoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid benzyl ester; With trifluoroacetic acid;

(S)-2-[(S)-2-{[(S)-2-((R)-2-Benzyloxycarbonylamino-pentanoylamino)-propionyl]-methyl-amino}-3-(4-methoxy-phenyl)-propionylamino]-propionic acid; With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In tetrahydrofuran; Further stages.;
DOI:10.1016/j.tetlet.2003.11.112

Reference yield:

: 86099-14-1
(2S)-3-(4-hydroxyphenyl)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid

: 694491-81-1
C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: 71 percent / EDC; HOBt; Et₃N / CH₂Cl₂

2.1: 100 percent / diethyl ether; methanol

3.1: H₂; HCl / Pd/C / methanol

4.1: PyBOP; i-Pr₂NEt / CH₂Cl₂

5.1: TFA

5.2: 99 percent / EDC; HOBt / CHCl₃

6.1: 99 percent / LiOH / tetrahydrofuran; methanol; H₂O

7.1: TFA

7.2: 90 percent / EDC; HOObt / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1016/j.tetlet.2003.11.112

Reference yield:

: 115441-64-0
methyl N-Cbz-N-methyl-L-tyrosyl-L-alaninate

: 694491-81-1
C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / diethyl ether; methanol

2.1: H₂; HCl / Pd/C / methanol

3.1: PyBOP; i-Pr₂NEt / CH₂Cl₂

4.1: TFA

4.2: 99 percent / EDC; HOBt / CHCl₃

5.1: 99 percent / LiOH / tetrahydrofuran; methanol; H₂O

6.1: TFA

6.2: 90 percent / EDC; HOObt / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1016/j.tetlet.2003.11.112