BenzenepropanaMide, 2-Methyl-

Base Information

• Chemical Name: BenzenepropanaMide, 2-Methyl-
• CAS No.: 103028-79-1
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 103028-79-1.mol

Synonyms:3-o-tolyl-propionic acid amide

Chemical Property of BenzenepropanaMide, 2-Methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BenzenepropanaMide, 2-Methyl-

There total 4 articles about BenzenepropanaMide, 2-Methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

acetamide (60-35-5) + 2-methyl-benzyl alcohol (89-95-2) → 3-o-tolyl-propionic acid amide (103028-79-1)

Guidance literature:

With tri-tert-butyl phosphine; potassium tert-butylate; nickel diacetate; In 1,4-dioxane; toluene; at 80 ℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1039/d0cc06468h

Reference yield: 82.0%

carbon monoxide (201230-82-2) + 1-methyl-2-vinyl-benzene (611-15-4) → 3-o-tolyl-propionic acid amide (103028-79-1)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); ammonium chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 24h; under 7600.51 Torr; Autoclave;

Reference yield:

carbon monoxide (201230-82-2) + 1-methyl-2-vinyl-benzene (611-15-4) → 2-o-tolyl-propionic acid amide (40089-18-7) + 3-o-tolyl-propionic acid amide (103028-79-1)

Guidance literature:

With ammonium chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium(II) iodide; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 4h; under 22801.5 Torr; Overall yield = 86 %; regioselective reaction;

DOI:10.1039/c7sc04054g

upstream raw materials:

3-(2-methylphenyl)propionic acid chloride

carbon monoxide

1-methyl-2-vinyl-benzene

acetamide

Downstream raw materials:

3-(2-Methylphenyl)propylamine

2-methylphenethylamine

Refernces

• 1、 Gao, Bao,Zhang, Guoying,Zhou, Xibing,Huang, Hanmin. "Palladium-catalyzed regiodivergent hydroaminocarbonylation of alkenes to primary amides with ammonium chloride". . p. 380 - 386. Retrieved 2018/01/12.