(2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate

Base Information

• Chemical Name: (2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate
• CAS No.: 1422263-51-1
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol file: 1422263-51-1.mol

Synonyms:(2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate

Chemical Property of (2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate

There total 3 articles about (2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diazoacetic acid ethyl ester (623-73-4) + glyoxylic acid ethyl ester (924-44-7) + 4-methoxy-aniline (104-94-9) → (2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate (1422263-51-1)

Guidance literature:

glyoxylic acid ethyl ester; 4-methoxy-aniline; With sodium sulfate; In benzene; at 20 ℃; for 0.5h;

diazoacetic acid ethyl ester; With boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1002/anie.201915438

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + ethyl (4-methoxyphenylimino)acetate (124156-21-4) → (2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate (1422263-51-1) + diethyl trans-1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate

Guidance literature:

With boron trifluoride diethyl etherate; In diethyl ether; at 20 ℃; Time; Temperature; stereoselective reaction;

DOI:10.1007/s11172-012-0121-7

Reference yield:

4-methoxy-aniline (104-94-9) → (2R,3S)-diethyl 1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate (1422263-51-1) + diethyl trans-1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfate / benzene / 20 °C

2: boron trifluoride diethyl etherate / diethyl ether / 20 °C

With boron trifluoride diethyl etherate; sodium sulfate; In diethyl ether; benzene;

DOI:10.1007/s11172-012-0121-7

upstream raw materials:

4-methoxy-aniline

diazoacetic acid ethyl ester

ethyl (4-methoxyphenylimino)acetate

glyoxylic acid ethyl ester

Downstream raw materials:

dimethyl cis-1-(4-methoxyphenyl)aziridine-2,3-dicarboxylate

C₁₅H₁₉NO₅

C₂₅H₂₁ClN₂O₇