tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate
CAS No.:447425-67-4
Molecular Formula:C₃₂H₃₆N₂O₄
Molecular Weight:512.649
Hs Code.:

Synonyms:tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

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Chemical Property of tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

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Technology Process of tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

There total 9 articles about tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 774532-23-9
C₂₇H₂₈N₂O₂

: 447425-67-4
tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₇H₂₄ClNO₃

: 447425-67-4
tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

2: thionyl chloride / toluene / 2 h / Reflux

3: N,N-dimethyl-formamide / 6 h / 20 °C

4: hydrazine hydrate / ethanol / 1 h / Reflux

5: tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; hydrazine hydrate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 447425-62-9
C₂₉H₂₉NO₄

: 447425-67-4
tert-butyl {[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / tetrahydrofuran; ethanol; water / 3 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

4: thionyl chloride / toluene / 2 h / Reflux

5: N,N-dimethyl-formamide / 6 h / 20 °C

6: hydrazine hydrate / ethanol / 1 h / Reflux

7: tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; oxalyl dichloride; hydrazine hydrate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059