tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate

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Chemical Name:tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate
CAS No.:1187450-42-5
Molecular Formula:C₃₃H₃₇BrN₆O₆S
Molecular Weight:725.663
Hs Code.:

Synonyms:tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate

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Chemical Property of tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate

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Technology Process of tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate

There total 6 articles about tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1187450-43-6
N-(6-phenylpyridazin-3-ylmethyl)pyridin-3-ylsulfonamide

: 1187450-44-7
tert-butyl [(5-bromo-6-bromomethylpyridin-2-yl) tert-butoxycarbonylamino]acetate

: 1187450-42-5
tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1187450-42-5
tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Cooling with ice

1.2: 2 h / 20 °C / Cooling with ice

2.1: N-Bromosuccinimide / acetonitrile / 3 h / 40 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / 1,2-dichloro-ethane / 1 h / 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 16133-25-8
Pyridine-3-sulfonyl chloride

: 1187450-42-5
tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 17 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;