721918-21-4Relevant articles and documents
Atropisomeric 3-(β-hydroxyethyl)-4-arylquinolin-2-ones as maxi-K potassium channel openers
Vrudhula, Vivekananda M.,Dasgupta, Bireshwar,Qian-Cutrone, Jingfang,Kozlowski, Edward S.,Boissard, Christopher G.,Dworetzky, Steven I.,Wu, Dedong,Gao, Qi,Kimura, Roy,Gribkoff, Valentin K.,Starrett Jr., John E.
, p. 1050 - 1057 (2008/02/02)
The synthesis of a series of 3-β-hydroxyethyl-4-arylquinolin-2-ones is described. These compounds contain hydrophilic and hydrophobic substituents ortho to the phenolic OH in the C ring of the quinolinone. Electrophysiological evaluation of the panel of c
ATROPISOMERS OF 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES
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Page/Page column 15; 27-28, (2010/02/07)
Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives having the general formula wherein R, R?1?, R?2?, R?3?, R?4? and R?5?, are as defined herein, or a non-toxic pharmaceutically acceptable salt, solvate or prodrug thereof. The atropisomers can