2-(4-nitrophenyl)-8-phenylthiooctanoic acid

Base Information

• Chemical Name: 2-(4-nitrophenyl)-8-phenylthiooctanoic acid
• CAS No.: 257289-11-5
• Molecular Formula: C₂₀H₂₃NO₄S
• Molecular Weight: 373.473
• Mol file: 257289-11-5.mol

Synonyms:2-(4-nitrophenyl)-8-phenylthiooctanoic acid

Chemical Property of 2-(4-nitrophenyl)-8-phenylthiooctanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-nitrophenyl)-8-phenylthiooctanoic acid

There total 5 articles about 2-(4-nitrophenyl)-8-phenylthiooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl [2-(4-nitrophenyl)-8-phenylthio]octanoate (161691-88-9) → 2-(4-nitrophenyl)-8-phenylthiooctanoic acid (257289-11-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1021/jo991139z

Reference yield:

1 ,6-dibromohexane (629-03-8) → 2-(4-nitrophenyl)-8-phenylthiooctanoic acid (257289-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / NaOH; Bu₄NBr / benzene; H₂O / 18 h / 48 °C

2: 77 percent / NaH / dimethylformamide / 48 h / 0 - 20 °C

3: 100 percent / aq. NaOH / ethanol / 2 h / Heating

With sodium hydroxide; tetrabutylammomium bromide; sodium hydride; In ethanol; water; N,N-dimethyl-formamide; benzene; 1: Condensation / 2: Alkylation / 3: Hydrolysis;

DOI:10.1021/jo991139z

Reference yield:

ETHYL 4-NITROPHENYLACETATE (5445-26-1) → 2-(4-nitrophenyl)-8-phenylthiooctanoic acid (257289-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / NaH / dimethylformamide / 48 h / 0 - 20 °C

2: 100 percent / aq. NaOH / ethanol / 2 h / Heating

With sodium hydroxide; sodium hydride; In ethanol; N,N-dimethyl-formamide; 1: Alkylation / 2: Hydrolysis;

DOI:10.1021/jo991139z

upstream raw materials:

ethyl [2-(4-nitrophenyl)-8-phenylthio]octanoate

1 ,6-dibromohexane

ETHYL 4-NITROPHENYLACETATE

(6-bromohexyl)(phenyl)sulfane

Downstream raw materials:

1-(4-aminophenyl)-7-phenylthioheptane

1-(4-azidophenyl)-7-phenylthioheptane

4-heptylaniline

1-(4-nitrophenyl)-7-phenylthioheptane