5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine

Base Information

Chemical Name:5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine
CAS No.:1311288-90-0
Molecular Formula:C₃₀H₄₃N₃O₃
Molecular Weight:493.69
Hs Code.:

Synonyms:5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine

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Chemical Property of 5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine

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Technology Process of 5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine

There total 7 articles about 5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1311288-87-5
5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4,6-dimethylpyrimidine

: 317801-83-5
1-bromo-9-(methoxymethoxy)nonane

: 1311288-90-0
5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; pentane; at -78 - 23 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 55362-80-6
9-bromononan-1-ol

: 1311288-90-0
5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 23 °C / Inert atmosphere

2: n-butyllithium / tetrahydrofuran; pentane / 0.5 h / 23 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; mineral oil; pentane;
DOI:10.1021/ml200095w

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1311288-90-0
5-(benzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(10-(methoxymethoxy)decyl)-6-methylpyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / water / 100 °C

2.1: N-Bromosuccinimide / acetonitrile / 3 h / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / toluene / 12 h / Reflux; Inert atmosphere

4.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

4.2: pH 2 - 3

5.1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 20 °C / Inert atmosphere

6.1: n-butyllithium / pentane; tetrahydrofuran / 0.5 h / -78 - 23 °C / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile; mineral oil; pentane;