1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

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Chemical Name:1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea
CAS No.:1315326-74-9
Molecular Formula:C₃₈H₄₀F₃N₇O₇S₂
Molecular Weight:827.906
Hs Code.:

1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Synonyms:1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

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Chemical Property of 1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

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Technology Process of 1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

There total 11 articles about 1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315326-73-8
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 1315326-74-9
1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Guidance literature:: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-(trifluoromethyl)phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride; 1,1'-Thiocarbonyldiimidazole; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With ammonia; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

Reference yield:

: 54802-10-7
3-aminobenzofuran-2-carboxamide

: 1315326-74-9
1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / tetrahydrofuran / 0 - 20 °C

2.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

2.2: pH ~ 2

3.1: trichlorophosphate / 1,4-dioxane / 6.5 h / 0 - 110 °C

3.2: pH 8

4.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 10 - 20 °C

4.2: 1 h / 20 °C

4.3: pH ~ 3

5.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 3 h / 20 °C

6.1: thionyl chloride / methanol / 5 h / 0 - 45 °C

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

8.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 - 4 °C

9.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

9.2: 3 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; triethylamine; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 611-20-1
salicylonitrile

: 1315326-74-9
1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonyl-carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-(trifluoromethyl)phenyl)-benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

1.2: 3 h / 80 °C

2.1: potassium tert-butylate / tert-butyl alcohol / 3 h / 80 °C

3.1: pyridine / tetrahydrofuran / 0 - 20 °C

4.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

4.2: pH ~ 2

5.1: trichlorophosphate / 1,4-dioxane / 6.5 h / 0 - 110 °C

5.2: pH 8

6.1: sodium t-butanolate / dimethyl sulfoxide / 2 h / 10 - 20 °C

6.2: 1 h / 20 °C

6.3: pH ~ 3

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 3 h / 20 °C

8.1: thionyl chloride / methanol / 5 h / 0 - 45 °C

9.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 20 °C

10.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 - 4 °C

11.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

11.2: 3 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; triethylamine; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;