1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline

Base Information

Chemical Name:1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline
CAS No.:798563-67-4
Molecular Formula:C₂₃H₂₃FN₂O₃
Molecular Weight:394.446
Hs Code.:

Synonyms:1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline

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Chemical Property of 1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline

Chemical Property:

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Technology Process of 1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline

There total 12 articles about 1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344689-14-0
C₂₂H₂₃ClFNO₃

: 143-33-9,25596-52-5
sodium cyanide

: 798563-67-4
1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline

Guidance literature:: In dimethyl sulfoxide; at 85 ℃; for 1h;

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 798563-67-4
1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol; sodium / toluene / 2 h / 80 - 85 °C

1.2: 2 h / 80 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

4.1: phosphorus pentachloride / dichloromethane

5.1: sulfur / 0.33 h / 165 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

7.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

8.1: dimethyl sulfoxide / 1 h / 85 °C

With hydrogenchloride; lithium aluminium tetrahydride; ethanol; phosphorus pentachloride; hydrogen; sodium; benzotriazol-1-ol; sulfur; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 36848-69-8
ethyl 2-cyano-2-(3,4-dimethoxyphenyl)acetate

: 798563-67-4
1-(2-fluoro-5-isopropoxy)benzyl-4-cyanomethyl-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

3: phosphorus pentachloride / dichloromethane

4: sulfur / 0.33 h / 165 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

6: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

7: dimethyl sulfoxide / 1 h / 85 °C

With hydrogenchloride; lithium aluminium tetrahydride; phosphorus pentachloride; hydrogen; benzotriazol-1-ol; sulfur; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;