AMINO-(2-METHOXY-PHENYL)-ACETIC ACID

Base Information

• Chemical Name: AMINO-(2-METHOXY-PHENYL)-ACETIC ACID
• CAS No.: 271583-17-6
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Hs Code.: 2922509090
• Mol file: 271583-17-6.mol

Synonyms:ALPHA-AMINO-(2-METHOXYPHENYL)ACETIC ACID;VITAS-BB TBB000094

Chemical Property of AMINO-(2-METHOXY-PHENYL)-ACETIC ACID

Chemical Property:

• Vapor Pressure: 2.6E-05mmHg at 25°C
• Boiling Point: 343.9°Cat760mmHg
• PKA: 1.78±0.10(Predicted)
• Flash Point: 161.8°C
• PSA: 72.55000
• Density: 1.246g/cm³
• LogP: 1.47990
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-2-(2-methoxyphenyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AMINO-(2-METHOXY-PHENYL)-ACETIC ACID

There total 8 articles about AMINO-(2-METHOXY-PHENYL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(benzylamino)-2-(2-methoxyphenyl)acetic acid (271583-23-4) → 2-amino-2-(2-methoxyphenyl)acetic acid (271583-17-6,103889-84-5,103889-86-7)

Guidance literature:

With sodium hydroxide; hydrazine hydrate; palladium on activated charcoal; In water; for 10h; Heating;

DOI:10.1080/00397910008087127

Reference yield: 55.0%

5-(2-methoxyphenyl)imidazolidine-2,4-dione (77651-54-8) → 2-amino-2-(2-methoxyphenyl)acetic acid (271583-17-6,103889-84-5,103889-86-7)

Guidance literature:

With potassium hydroxide; In water; for 60h; Reflux;

Reference yield: 18.0%

2-methoxy phenylglycine methyl ester (77651-55-9) → 2-amino-2-(2-methoxyphenyl)acetic acid (271583-17-6,103889-84-5,103889-86-7)

Guidance literature:

With potassium hydroxide; In water; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01302

upstream raw materials:

5-(2-methoxyphenyl)imidazolidine-2,4-dione

2-(benzylamino)-2-(2-methoxyphenyl)acetic acid

ortho-anisaldehyde

2-(benzylamino)-2-(2-methoxyphenyl)acetonitrile

Downstream raw materials:

2-(2-methoxy-phenyl)-4-methyl-quinazoline

tert-butoxy-carbonylamino-(2-methoxy-phenyl)-acetic acid

Refernces

• 1、 Inada, Haruki,Shibuya, Masatoshi,Yamamoto, Yoshihiko. "Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine". . p. 11047 - 11059. Retrieved 2020/10/12.
• 2、 Daum, S. J.,Hansen, P. E.. "SYNTHESIS OF 2,3-BENZO-1-OXAOCTEM-4-CARBOXYLIC ACID". . p. 1 - 6. Retrieved 2007/10/02.