2-methoxy phenylglycine methyl ester

Base Information

• Chemical Name: 2-methoxy phenylglycine methyl ester
• CAS No.: 77651-55-9
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 77651-55-9.mol

Synonyms:2-methoxy phenylglycine methyl ester

Chemical Property of 2-methoxy phenylglycine methyl ester

Chemical Property:

• Boiling Point: 294.6±30.0 °C(Predicted)
• Density: 1.143±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Amino-(2-methoxy-phenyl)-aceticacidmethylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy phenylglycine methyl ester

There total 3 articles about 2-methoxy phenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methanol (67-56-1) + 2-amino-2-(2-methoxyphenyl)acetic acid (271583-17-6,103889-84-5,103889-86-7) → 2-methoxy phenylglycine methyl ester (77651-55-9)

Guidance literature:

With hydrogenchloride;

Reference yield:

methanol (67-56-1) + potassium cyanide + ortho-anisaldehyde (135-02-4) → 2-methoxy phenylglycine methyl ester (77651-55-9)

Guidance literature:

potassium cyanide; ortho-anisaldehyde; With ammonium chloride; In methanol; water; at 0 - 20 ℃; for 5h; Inert atmosphere;

In water; for 13h; Reflux; Inert atmosphere;

methanol; With thionyl chloride; at 0 ℃; for 7h; Reflux; Inert atmosphere;

DOI:10.1021/acs.joc.0c01302

Reference yield:

5-(2-methoxyphenyl)imidazolidine-2,4-dione (77651-54-8) → 2-methoxy phenylglycine methyl ester (77651-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / aq. NAOH

2: 74 percent / aq. HCl

With hydrogenchloride; sodium hydroxide;

upstream raw materials:

methanol

2-amino-2-(2-methoxyphenyl)acetic acid

5-(2-methoxyphenyl)imidazolidine-2,4-dione

ortho-anisaldehyde

Downstream raw materials:

N-[2-hydroxy-1-(2-methoxyphenyl)ethyl]octanamide

2-amino-2-(2-methoxyphenyl)acetic acid

(2-Methoxy-phenyl)-methylsulfanylmethyleneamino-acetic acid methyl ester

[formyl-(2-{[methoxycarbonyl-(4-methoxy-phenyl)-methyl]-amino}-ethyl)-amino]-(2-methoxy-phenyl)-acetic acid methyl ester