2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine

Base Information

Chemical Name:2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine
CAS No.:1375182-81-2
Molecular Formula:C₁₆H₁₄FN₉S
Molecular Weight:383.412
Hs Code.:

Synonyms:2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine

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Chemical Property of 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine

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Technology Process of 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine

There total 5 articles about 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1375183-38-2
2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)-5-(phenyldiazenyl)pyrimidine-4,6-diamine

: 1375182-81-2
2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine

Guidance literature:: With sodium dithionite; sodium hydroxide; In N,N-dimethyl-formamide; at 150 ℃; for 2h;

Reference yield:

: 1375183-36-0
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carbonitrile

: 1375182-81-2
2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate; methanol / 5 h / 20 °C

1.2: 17 h / 20 °C

2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 26 h / 110 °C / sealed tube

3.1: sodium hydroxide; sodium dithionite / N,N-dimethyl-formamide / 2 h / 150 °C

With pyridine; methanol; sodium dithionite; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1375183-33-7
ethyl 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboxylate

: 1375182-81-2
2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia; sodium cyanide / methanol / 24 h / 90 °C / Sealed tube

2.1: trifluoroacetic anhydride; pyridine / 2.08 h / 0 - 20 °C

3.1: sodium methylate; methanol / 5 h / 20 °C

3.2: 17 h / 20 °C

4.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 26 h / 110 °C / sealed tube

5.1: sodium hydroxide; sodium dithionite / N,N-dimethyl-formamide / 2 h / 150 °C

With pyridine; methanol; sodium cyanide; sodium dithionite; ammonia; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide;