N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide

Base Information

• Chemical Name: N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide
• CAS No.: 264603-73-8
• Molecular Formula: C₂₃H₁₈N₄O₂
• Molecular Weight: 382.422

Synonyms:N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide

Chemical Property of N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide

Chemical Property:

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Technology Process of N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide

There total 1 articles about N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dmap (1122-58-3) + 2-(4-Aminophenyl)-2-phenylacetonitrile (4760-58-1) + N-ethyl-N,N-diisopropylamine (7087-68-5) + (+/-)-methyl 4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxylate (264606-30-6) → N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide (264603-73-8)

Guidance literature:

In dichloromethane; water; ethyl acetate;

Reference yield: 10.0%

N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide (264603-73-8) → (+/-)-N-[4-[2-amino-2-(hydroxyimino)-1-phenylethyl]phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide (264606-06-6)

Guidance literature:

With hydroxylamine; triethylamine; In tetrahydrofuran; CH₂Cl₂/CH₃OH; ethanol; water;

Reference yield: 8.0%

N-[4-(cyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide (264603-73-8) + poly(oxymethylene) + N-benzyl-trimethylammonium hydroxide (100-85-6) → (+/-)-N-[4-(1-cyano-2-hydroxy-1-phenylethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide (264606-05-5)

Guidance literature:

In pyridine;

upstream raw materials:

dmap

2-(4-Aminophenyl)-2-phenylacetonitrile

N-ethyl-N,N-diisopropylamine

(+/-)-methyl 4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxylate

Downstream raw materials:

(+/-)-N-[4-(1-cyano-2-hydroxy-1-phenylethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide

(+/-)-N-[4-[2-amino-2-(hydroxyimino)-1-phenylethyl]phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide

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