3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane

Base Information

• Chemical Name: 3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane
• CAS No.: 178626-04-5
• Molecular Formula: C₁₈H₂₉NO
• Molecular Weight: 275.434
• Mol file: 178626-04-5.mol

Synonyms:3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane

Chemical Property of 3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane

There total 9 articles about 3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + trifluoro(3-phenylpropyl)-λ4-borane potassium salt → 3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane (178626-04-5)

Guidance literature:

With silver(l) oxide; In water; toluene; at 20 ℃; for 0.166667h; Inert atmosphere; Sealed tube;

Reference yield: 30.0%

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + 1-iodo-3-phenylpropan (4119-41-9) → 3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane (178626-04-5)

Guidance literature:

With phenylsilane; C₂₁H₂₃Cl₃CuN₂; nitrobenzene; sodium hydroxide; In 1,4-dioxane; at 70 ℃; for 30h; Glovebox;

DOI:10.1021/acs.orglett.9b04092

Reference yield: 28.0%

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical (2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3) + carbon monoxide (201230-82-2) + 1-iodo-3-phenylpropan (4119-41-9) → 3-phenyl-1-(2′,2′,6′,6′-tetramethyl-1′-piperidinyloxy)-propane (178626-04-5)

Guidance literature:

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; carbon monoxide; 1-iodo-3-phenylpropan; With diethoxymethylane; [CuCl(IPr^Me)]; lithium methanolate; In tetrahydrofuran; at 60 ℃; for 16h; under 2280.15 Torr; Sealed tube;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;

DOI:10.1002/anie.201801814

upstream raw materials:

2,2,6,6-tetramethyl-1-oxo-piperidinium

3-phenylpropylmagnesium bromide

allylbenzene

N-phenyl-maleimide

Downstream raw materials:

2,2,6,6-tetramethylpiperidin-1-ol

<1-3H>-3-phenylpropanal

3-phenyl-propionaldehyde