Technology Process of Methyl (1R,2S,3R)-1,3-Dimethyl-1-hydroxy-2<2-(3-isopropylphenyl)-ethyl>cyclohexanecarboxylate
There total 8 articles about Methyl (1R,2S,3R)-1,3-Dimethyl-1-hydroxy-2<2-(3-isopropylphenyl)-ethyl>cyclohexanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1: 1) Mg; 3) p-TsOH / 1) THF; 2) THF, -78 deg C, 2 h; 3) MeOH, reflux, 10 h
2: Et3N / CH2Cl2 / 1 h / 0 °C
3: 76 percent / NaI / acetone / 10 h / Heating
4: 1) NaH; 2) NaOMe; 3) TiCl3, NH4OAc / 1) DMF, 0 deg C, 24 h; 2) MeOH, room temp., 1 h; 3) H2O, 0 deg C, then room temp., 2 h
5: 100 percent / tetrahydrofuran / 2 h / 0 °C
With
titanium(III) chloride; ammonium acetate; sodium methylate; sodium hydride; toluene-4-sulfonic acid; magnesium; triethylamine; sodium iodide;
In
tetrahydrofuran; dichloromethane; acetone;
DOI:10.1248/cpb.39.202
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent / PPh3, N-bromosuccinimide / tetrahydrofuran / 2 h / Ambient temperature
2: 1) Mg; 3) p-TsOH / 1) THF; 2) THF, -78 deg C, 2 h; 3) MeOH, reflux, 10 h
3: Et3N / CH2Cl2 / 1 h / 0 °C
4: 76 percent / NaI / acetone / 10 h / Heating
5: 1) NaH; 2) NaOMe; 3) TiCl3, NH4OAc / 1) DMF, 0 deg C, 24 h; 2) MeOH, room temp., 1 h; 3) H2O, 0 deg C, then room temp., 2 h
6: 100 percent / tetrahydrofuran / 2 h / 0 °C
With
N-Bromosuccinimide; titanium(III) chloride; ammonium acetate; sodium methylate; sodium hydride; toluene-4-sulfonic acid; magnesium; triethylamine; triphenylphosphine; sodium iodide;
In
tetrahydrofuran; dichloromethane; acetone;
DOI:10.1248/cpb.39.202
