3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one

Base Information

Chemical Name:3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one
CAS No.:875270-42-1
Molecular Formula:C₂₇H₂₆BrN₃O₂
Molecular Weight:504.426
Hs Code.:

Synonyms:3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one

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Chemical Property of 3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one

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Technology Process of 3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one

There total 2 articles about 3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 404835-95-6
6-bromo-2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one

: 110859-47-7,140646-11-3
(4-benzylmorpholin-2-yl)methanamine

: 875270-42-1
3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one

Guidance literature:: 6-bromo-2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one; (4-benzylmorpholin-2-yl)methanamine; In toluene; for 16h; Heating;

With lithium hydroxide; In ethylene glycol; at 135 ℃; for 16h; Further stages.;
DOI:10.1021/jm070071+

Reference yield:

: C₂₇H₂₈BrN₃O₃

: 875270-42-1
3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one

Guidance literature:: With lithium hydroxide; In ethylene glycol; at 135 ℃; for 16h;

Reference yield: 76.0%

: 875270-42-1
3-[(4-benzylmorpholin-2-yl)methyl]-6-bromo-2-(2-methylphenyl)quinazolin-4(3H)-one

: 1679-18-1
4-Chlorophenylboronic acid

: 875259-72-6
3-[(4-benzylmorpholin-2-yl)methyl]-6-(4-chlorophenyl)-2-(2-methylphenyl)quinazolin-4(3H)-one

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; toluene; at 90 ℃; for 12h;
DOI:10.1021/jm070071+