benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

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Chemical Name:benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester
CAS No.:1434818-13-9
Molecular Formula:C₂₀H₂₀F₃N₃O₅S
Molecular Weight:471.457
Hs Code.:

Synonyms:benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

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Chemical Property of benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

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Technology Process of benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

There total 8 articles about benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1434816-31-5
(2S,4S)-4-hydroxy-1-(1-trifluoromethylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide

: 98-09-9
benzenesulfonyl chloride

: 1434818-13-9
benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 2 - 20 ℃; for 20.25h;

Reference yield:

: (1S,4S)-3-oxo-2-oxa-5-azonia-bicyclo [2.2.1]heptane methanesulfonate

: 1434818-13-9
benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / toluene; N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 0 - 20 °C

2: sodium 2-ethylhexanoic acid / water / 20 h / 53 °C

3: triethylamine; dmap / tetrahydrofuran / 20.25 h / 2 - 20 °C

With dmap; triethylamine; sodium 2-ethylhexanoic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 87250-97-3,113775-22-7
2’-methyl-2’-propanyl (1S,4S)-3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate

: 1434818-13-9
benzenesulfonic acid (3S,5S)-5-(1-cyano-cyclopropylcarbamoyl)-1-(1-trifluoromethylcyclopropanecarbonyl)-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: ethyl acetate / 16 h / 45 °C

2: triethylamine / toluene; N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 0 - 20 °C

3: sodium 2-ethylhexanoic acid / water / 20 h / 53 °C

4: triethylamine; dmap / tetrahydrofuran / 20.25 h / 2 - 20 °C

With dmap; triethylamine; sodium 2-ethylhexanoic acid; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; toluene;