4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride

Base Information

• Chemical Name: 4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride
• CAS No.: 478157-91-4
• Molecular Formula: C₃₀H₃₈ClNO₃*ClH
• Molecular Weight: 532.551
• Mol file: 478157-91-4.mol

Synonyms:4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride

Chemical Property of 4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride

There total 10 articles about 4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride (478157-85-6) → 4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride (478157-91-4) + C30H38ClNO3*ClH

Guidance literature:

With hydrogenchloride; N-chloro-succinimide; In methanol; dichloromethane; water;

DOI:10.1021/op0341622

Reference yield:

C32H40ClNO4*ClH → 4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride (478157-91-4) + C30H36ClNO2

Guidance literature:

With potassium hydroxide; In methanol; at 0 - 5 ℃; for 1.5h;

DOI:10.1021/op0341622

Reference yield:

C23H36O4Si → 4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride (478157-91-4) + C30H36ClNO2

Guidance literature:

Multi-step reaction with 4 steps

1.1: copper(l) chloride / tetrahydrofuran / 0 °C

1.2: 10 - 15 °C

2.1: thionyl chloride; pyridine / dichloromethane / 2 h / -40 - 20 °C

2.2: 0.25 h

3.1: acetic anhydride / dichloromethane / 6 h / 20 - 25 °C

4.1: potassium hydroxide / methanol / 1.5 h / 0 - 5 °C

With pyridine; thionyl chloride; acetic anhydride; copper(l) chloride; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/op0341622

upstream raw materials:

11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione

11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride

4-bromo-phenol

4-(2-(diethylamino)ethoxy)bromobenzene