4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE

Base Information

• Chemical Name: 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE
• CAS No.: 1823-62-7
• Molecular Formula: C12H18BrNO
• Molecular Weight: 272.185
• Hs Code.: 2922299090
• Mol file: 1823-62-7.mol

Synonyms:1-Bromo-4-(diethylaminoethoxy)benzene;2-(p-Bromophenoxy)triethylamine;Triethylamine,2-(p-bromophenoxy)- (7CI,8CI);2-(4-Bromophenoxy)triethylamine;4-(2-Diethylaminoethoxy)phenyl bromide;

Chemical Property of 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE

Chemical Property:

• Vapor Pressure: 0.000338mmHg at 25°C
• Refractive Index: 1.527
• Boiling Point: 319.5 °C at 760 mmHg
• PKA: 9.54±0.25(Predicted)
• Flash Point: 147 °C
• PSA: 12.47000
• Density: 1.24 g/cm³
• LogP: 3.16970

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Bromophenoxy)-N,N-diethylethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE

There total 5 articles about 4-[2-N,N-DIETHYLETHOXY]PHENYL BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

4-bromo-phenol (106-41-2) + 2-chloro-N,N-diethylethylamine hydrochloride (869-24-9) → 4-(2-(diethylamino)ethoxy)bromobenzene (1823-62-7)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In dichloromethane; water; at 25 - 35 ℃; for 18h;

DOI:10.1021/op0341622

Reference yield:

4-bromo-phenol (106-41-2) + 2-(diethylamino)ethyl chloride (100-35-6) → 4-(2-(diethylamino)ethoxy)bromobenzene (1823-62-7)

Guidance literature:

Multistep reaction; (i) Na, (ii) /BRN= 605300/;

DOI:10.1021/jm00326a018

Reference yield:

methanol (67-56-1) + 4-bromo-phenol (106-41-2) + sodium 4-bromophenoxide (7003-65-8) → 4-(2-(diethylamino)ethoxy)bromobenzene (1823-62-7)

Guidance literature:

With sodium hydroxide; sodium methylate; In water; chlorobenzene;

upstream raw materials:

4-bromo-phenol

2-(diethylamino)ethyl chloride

2-chloro-N,N-diethylethylamine hydrochloride

sodium 4-bromophenoxide

Downstream raw materials:

1-[4-(2-Diethylamino-ethoxy)-phenyl]-1-(4-fluor-phenyl)-ethanol

[2-(4-Bromo-phenoxy)-ethyl]-(2-chloro-benzyl)-diethyl-ammonium; iodide

3-<4-(2-Diaethylamino-aethoxy)-phenyl>-inden

<4-(2-Diethylaminoethoxy)phenyl>methoxy(4-methoxybenzyl)phenylsilan

Refernces

• 1、 Prat, Denis,Benedetti, Francoise,Girard, Gilles Franc,Bouda, Lahlou Nait,Larkin, John,Wehrey, Christian,Lenay, Jacques. "Industrial synthesis of 4-chloro, 11β-arylestradiol: How to circumvent a poor diastereoselectivity". . p. 219 - 228. Retrieved 2013/09/04.
• 2、 Fan, Qu-Li,Lu, Su,Lai, Yee-Hing,Hou, Xiao-Yuan,Huang, Wei. "Synthesis, characterization, and fluorescence quenching of novel cationic phenyl-substituted poly(p-phenylenevinylene)s". . p. 6976 - 6984. Retrieved 2007/10/03.