3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

Base Information

• Chemical Name: 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide
• CAS No.: 38938-59-9
• Molecular Formula: C₁₄H₁₃NO₂S
• Molecular Weight: 259.329
• Mol file: 38938-59-9.mol

Synonyms:3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

Chemical Property of 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

There total 6 articles about 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(4-methylphenyl)-1,2-benzoisothiazole 1,1-dioxide (38938-54-4) → 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide (38938-59-9)

Guidance literature:

With water; sodium acetate; cobalt(II) iodide; zinc; In acetonitrile; at 80 ℃; for 7h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201900636

Reference yield: 89.0%

N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide (1009806-74-9) → 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide (38938-59-9)

Guidance literature:

With chloro-trimethyl-silane; iodine; sodium iodide; In acetonitrile; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.3987/COM-09-11884

Reference yield:

N-tert-butylbenzenesulfonamide (2512-24-5) → 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide (38938-59-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 2.33 h / 0 °C / Inert atmosphere; Schlenk technique

2.1: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere; Schlenk technique

3.1: sodium tetrahydroborate / methanol

With sodium tetrahydroborate; n-butyllithium; pyridinium chlorochromate; In tetrahydrofuran; methanol; hexane; dichloromethane;

DOI:10.1039/c6cc09493g

upstream raw materials:

3-(4-methylphenyl)-1,2-benzoisothiazole 1,1-dioxide

N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide

N-tert-butylbenzenesulfonamide

4-methyl-benzaldehyde

Downstream raw materials:

3-(4-methylphenyl)-1,2-benzoisothiazole 1,1-dioxide