N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide

Base Information

Chemical Name:N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide
CAS No.:405551-81-7
Molecular Formula:C₄₀H₃₇ClN₄O
Molecular Weight:625.213
Hs Code.:

<i>N</i>-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-<i>N</i>-methyl-3-(1-trityl-1<i>H</i>-imidazol-4-yl)-propionamide

Synonyms:N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide

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Chemical Property of N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide

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Technology Process of N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide

There total 5 articles about N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 405551-80-6
N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide

: 74-88-4
methyl iodide

: 405551-81-7
N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide

Guidance literature:: With sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(03)00357-3

Reference yield:

: 6318-51-0
2-(4-chlorobenzoyl)pyridine

: 405551-81-7
N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / NaH / tetrahydrofuran

2: 78 percent / NaBH₄ / propan-2-ol / Heating

3: 36 percent / LiAlH₄ / diethyl ether / Heating

4: 80 percent / Me₃Al / toluene

5: 94 percent / NaH / tetrahydrofuran

With sodium tetrahydroborate; lithium aluminium tetrahydride; trimethylaluminum; sodium hydride; In tetrahydrofuran; diethyl ether; isopropyl alcohol; toluene; 1: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/S0960-894X(03)00357-3

Reference yield:

: 20619-13-0
Didesmethylchlorpheniramine

: 405551-81-7
N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-N-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Me₃Al / toluene

2: 94 percent / NaH / tetrahydrofuran

With trimethylaluminum; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1016/S0960-894X(03)00357-3