7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Base Information

Chemical Name:7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
CAS No.:139524-73-5
Molecular Formula:C₂₁H₁₇F₃N₄O₄
Molecular Weight:446.386
Hs Code.:

Synonyms:7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Chemical Property of 7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Technology Process of 7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

There total 8 articles about 7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 593-56-6
N-methoxylamine hydrochloride

: 139524-67-7
7-(4-oxopiperidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 139524-73-5
7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With sodium hydrogencarbonate; In ethanol; at 45 ℃; for 20h;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 139524-73-5
7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / p-toluenesulfonic acid / toluene / 96 h / 130 °C

2: 99 percent / H₂ / 20percent Pd/C / ethyl acetate; methanol / 24 h / Ambient temperature

3: Et₃N / pyridine / 24 h / Ambient temperature

4: 3 M aq. HCl / tetrahydrofuran / 38 h / 70 °C

5: 94 percent / aq. NaHCO₃ / ethanol / 20 h / 45 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; ethyl acetate; toluene;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 139524-73-5
7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1 M aq. NaOH / diethyl ether / 3 h

2: 91 percent / pyridine-SO₃, Et₃N / dimethylsulfoxide / 1 h / 0 °C

3: 91 percent / p-toluenesulfonic acid / toluene / 96 h / 130 °C

4: 99 percent / H₂ / 20percent Pd/C / ethyl acetate; methanol / 24 h / Ambient temperature

5: Et₃N / pyridine / 24 h / Ambient temperature

6: 3 M aq. HCl / tetrahydrofuran / 38 h / 70 °C

7: 94 percent / aq. NaHCO₃ / ethanol / 20 h / 45 °C

With hydrogenchloride; sodium hydroxide; hydrogen; sulfur trioxide pyridine complex; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dimethyl sulfoxide; ethyl acetate; toluene;