tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate
CAS No.:1451998-62-1
Molecular Formula:C₁₅H₁₈F₃NO₄S
Molecular Weight:365.373
Hs Code.:

Synonyms:tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate

There total 5 articles about tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451998-40-5
tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate

: 1451998-62-1
tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate

Guidance literature:: With sodium periodate; tetrabutylammonium perruthenate; In dichloromethane; water; acetonitrile; at 20 ℃; for 0.25h;

Reference yield:

: 106-53-6
para-bromobenzenethiol

: 1451998-62-1
tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / water; acetonitrile / -78 - 20 °C

2: tert.-butyl lithium / diethyl ether; hexane / 2.08 h / -78 - 20 °C / Inert atmosphere

3: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

4: tetrabutylammonium perruthenate; sodium periodate / water; dichloromethane; acetonitrile / 0.25 h / 20 °C

With sodium periodate; diethylamino-sulfur trifluoride; tetrabutylammonium perruthenate; tert.-butyl lithium; potassium hydroxide; In diethyl ether; hexane; dichloromethane; water; acetonitrile;

Reference yield:

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: 1451998-62-1
tert-butyl 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tert.-butyl lithium / diethyl ether; hexane / 2.08 h / -78 - 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

3: tetrabutylammonium perruthenate; sodium periodate / water; dichloromethane; acetonitrile / 0.25 h / 20 °C

With sodium periodate; diethylamino-sulfur trifluoride; tetrabutylammonium perruthenate; tert.-butyl lithium; In diethyl ether; hexane; dichloromethane; water; acetonitrile;