tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate
CAS No.:1451998-40-5
Molecular Formula:C₁₅H₁₈F₃NO₂S
Molecular Weight:333.375
Hs Code.:

Synonyms:tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate

There total 4 articles about tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451998-39-2
tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-hydroxyazetidine-1-carboxylate

: 1451998-40-5
tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 ℃; for 0.25h;

Reference yield:

: 106-53-6
para-bromobenzenethiol

: 1451998-40-5
tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / water; acetonitrile / -78 - 20 °C

2: tert.-butyl lithium / diethyl ether; hexane / 2.08 h / -78 - 20 °C / Inert atmosphere

3: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

With diethylamino-sulfur trifluoride; tert.-butyl lithium; potassium hydroxide; In diethyl ether; hexane; dichloromethane; water; acetonitrile;

Reference yield:

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: 1451998-40-5
tert-butyl 3-(4-((difluoromethyl)thio)phenyl)-3-fluoroazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butyl lithium / diethyl ether; hexane / 2.08 h / -78 - 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

With diethylamino-sulfur trifluoride; tert.-butyl lithium; In diethyl ether; hexane; dichloromethane;