ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

Base Information

Chemical Name:ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate
CAS No.:128972-17-8
Molecular Formula:C₂₃H₂₄N₆O₂
Molecular Weight:416.483
Hs Code.:

Synonyms:ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

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Chemical Property of ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

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Technology Process of ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

There total 1 articles about ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3099-31-8
nicotinyl chloride

: 128972-13-4
ethyl 8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]-pyrazin-3-ylacetate

: 128972-17-8
ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

Guidance literature:: With sodium hydride; Multistep reaction; 1.) DMF, 0 deg C, 2.) 2 h;
DOI:10.1021/jm00171a005

Reference yield:

: 128972-17-8
ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

: 128972-42-9,129096-85-1
(3S,4S)-3-Hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-6-methyl-heptanoic acid [(S)-1-(3-aminomethyl-benzylcarbamoyl)-3-methyl-butyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 2 M aq. NaOH / ethanol / 1 h

2: triethylamine, 1-hydroxybenzotriazole (HOBT), ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C

3: H₂ / 10percent Pd/C / ethanol / 1 h / 20 °C

With sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005

Reference yield:

: 128972-17-8
ethyl 2-[8-propyl-6-(pyridin-3-yl)-1,2,4-triazolo[4,3-a]pyrazin-3-yl]-3-(pyridin-3-yl)propionate

: 128972-43-0
4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2 M aq. NaOH / ethanol / 1 h

2: triethylamine, 1-hydroxybenzotriazole (HOBT), ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C

3: H₂ / 10percent Pd/C / ethanol / 1 h / 20 °C

With sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005