3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

Base Information

Chemical Name:3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester
CAS No.:1186234-50-3
Molecular Formula:C₁₅H₁₂IN₃O₅
Molecular Weight:441.182
Hs Code.:

Synonyms:3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

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Chemical Property of 3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

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Technology Process of 3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

There total 2 articles about 3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1186234-48-9
2-(1-benzhydryl-azetidin-3-yloxy)-5-iodo-pyridine

: 7693-46-1
4-Nitrophenyl chloroformate

: 1186234-50-3
3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 69045-79-0
2-choro-5-iodopyridine

: 1186234-50-3
3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

1.2: 70 °C / Inert atmosphere

2.1: dichloromethane / 18 h / 20 °C

With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1186234-50-3
3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid 4-nitro-phenyl ester

: 1186234-39-8
3-[5-(2-fluoro-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice; Inert atmosphere

1.2: 20 °C / Cooling with ice; Inert atmosphere

2.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.5 h / 100 °C / Microwave irradiation; Inert atmosphere

With sodium hydride; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;