benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate
• CAS No.: 1010830-52-0
• Molecular Formula: C₂₈H₂₇N₃O₃
• Molecular Weight: 453.541

Synonyms:benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate

Chemical Property of benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate

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Technology Process of benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate

There total 1 articles about benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1R)-1-phenylethyl isocyanate (33375-06-3) + 4-benzylamino-1H-pyrrole-2-carboxylic acid benzyl ester (605629-49-0) → benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate (1010830-52-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1021/ol702994g

Reference yield: 57.0%

benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate (1010830-52-0) + isobutyraldehyde (78-84-2) → benzyl 4-(1-benzyl-3-((R)-1-phenylethyl)ureido)-5-(2-methylprop-1-enyl)-1H-pyrrole-2-carboxylate (1010830-65-5)

Guidance literature:

With trifluoroacetic acid; at 140 ℃; for 2.5h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/ol702994g

Reference yield: 52.0%

benzyl 4-(1-benzyl-3((R)-1-phenylethyl)ureido)-1H-pyrrole-2-carboxylate (1010830-52-0) + isovaleraldehyde (590-86-3) → benzyl 4-(1-benzyl-3-((R)-1-phenylethyl)ureido)-5-((E)-3-methylbut-1-enyl)-1H-pyrrole-2-carboxylate (1010830-66-6)

Guidance literature:

With trifluoroacetic acid; at 140 ℃; for 2.5h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/ol702994g

upstream raw materials:

(1R)-1-phenylethyl isocyanate

4-benzylamino-1H-pyrrole-2-carboxylic acid benzyl ester

Downstream raw materials:

benzyl 4-(1-benzyl-3-((R)-1-phenylethyl)ureido)-5-((E)-prop-1-enyl)-1H-pyrrole-2-carboxylate

benzyl 4-(1-benzyl-3-((R)-1-phenylethyl)ureido)-5-(2-methylprop-1-enyl)-1H-pyrrole-2-carboxylate

benzyl 4-(1-benzyl-3-((R)-1-phenylethyl)ureido)-5-((E)-3-methylbut-1-enyl)-1H-pyrrole-2-carboxylate

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