METHYL 3-(2-OXOPYRROLIDIN-1-YL) PROPANOATE

Base Information

• Chemical Name: METHYL 3-(2-OXOPYRROLIDIN-1-YL) PROPANOATE
• CAS No.: 24299-77-2
• Molecular Formula: C8H13 N O3
• Molecular Weight: 171.196
• Hs Code.: 2933790090
• Mol file: 24299-77-2.mol

Synonyms:1-Pyrrolidinepropionicacid, 2-oxo-, methyl ester (8CI)

Chemical Property of METHYL 3-(2-OXOPYRROLIDIN-1-YL) PROPANOATE

Chemical Property:

• PSA: 46.61000
• LogP: 0.10980

Purity/Quality:

95% ^*data from raw suppliers

Methyl 3-(2-oxopyrrolidin-1-yl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-(2-OXOPYRROLIDIN-1-YL) PROPANOATE

There total 6 articles about METHYL 3-(2-OXOPYRROLIDIN-1-YL) PROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-pyrrolidinon (616-45-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(2'-oxo-1'-pyrrolidinyl)propanoate (24299-77-2)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In 1,4-dioxane; for 72h; Ambient temperature;

Reference yield: 70.0%

methanol (67-56-1) + 3-(2-oxopyrrolidin-1-yl)propanenitrile (7663-76-5) → methyl 3-(2'-oxo-1'-pyrrolidinyl)propanoate (24299-77-2)

Guidance literature:

With toluene-4-sulfonic acid; for 20h; Heating;

DOI:10.1248/cpb.28.3632

Reference yield:

methanol (67-56-1) + C11H19NO5 → methyl 3-(2'-oxo-1'-pyrrolidinyl)propanoate (24299-77-2)

Guidance literature:

methanol; C₁₁H₁₉NO₅; With triethylamine; at 20 ℃; for 4h; Inert atmosphere;

With sodium cyanoborohydride; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.05.081

upstream raw materials:

methanol

3-(2-oxopyrrolidin-1-yl)propanenitrile

2-pyrrolidinon

acrylic acid methyl ester

Downstream raw materials:

3-(2-oxopyrrolidin-1-yl)propionic acid

N-<2-(3,4-dimethoxyphenyl)ethyl>-3-(2-oxo-1-pyrrolidinyl)propionamide

3-pyrrolidin-1-yl-propan-1-ol

6,7-dimethoxy-1-<2-(2-oxo-1-pyrrolidinyl)ethyl>-1,2,3,4-tetrahydroisoquinoline