N¹-benzoyl-N²-(3-indolyl)hydrazine

Base Information

• Chemical Name: N¹-benzoyl-N²-(3-indolyl)hydrazine
• CAS No.: 82380-78-7
• Molecular Formula: C₁₆H₁₃N₃O₂
• Molecular Weight: 279.298
• Mol file: 82380-78-7.mol

Synonyms:N¹-benzoyl-N²-(3-indolyl)hydrazine

Chemical Property of N¹-benzoyl-N²-(3-indolyl)hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-benzoyl-N²-(3-indolyl)hydrazine

There total 4 articles about N¹-benzoyl-N²-(3-indolyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1H-indole-3-carboxylic acid hydrazide (15317-58-5) + benzoyl chloride (98-88-4) → N1-benzoyl-N2-(3-indolyl)hydrazine (82380-78-7)

Guidance literature:

In pyridine; for 2.5h; Heating;

DOI:10.1007/BF00522123

Reference yield:

1H-indole-3-carboxylic acid (771-50-6) + benzoic acid hydrazide (613-94-5) → N1-benzoyl-N2-(3-indolyl)hydrazine (82380-78-7)

Guidance literature:

1H-indole-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 0.25h;

benzoic acid hydrazide; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2010.07.023

Reference yield:

3-methoxycarbonylindole (942-24-5) → N1-benzoyl-N2-(3-indolyl)hydrazine (82380-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / hydrazine hydrate / ethane-1,2-diol / 20 h / 110 °C

2: 71 percent / pyridine / 2.5 h / Heating

With hydrazine hydrate; In pyridine; ethylene glycol;

DOI:10.1007/BF00522123

upstream raw materials:

1H-indole-3-carboxylic acid hydrazide

benzoyl chloride

3-methoxycarbonylindole

1H-indole-3-carboxylic acid

Downstream raw materials:

2-1H-indol-3-yl-5-phenyl-1,3,4-thiadiazole

2-(1H-indol-3-yl)-5-phenyl-1,3,4-oxadiazole

2-(1H-indol-2-yl)-5-phenyl-1,3,4-oxadiazole

Refernces

• 1、 Kelarev,Shvekhgeimer. "Synthesis and properties of azoles and their derivatives. 33. Synthesis of 1,3,4-oxadiazoles that contain an indolyl group". . p. 258 - 261. Retrieved 2007/10/02.