N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide

Base Information

Chemical Name:N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide
CAS No.:1012056-56-2
Molecular Formula:C₂₇H₂₇N₅O₃S
Molecular Weight:501.609
Hs Code.:

Synonyms:N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide

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Chemical Property of N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide

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Technology Process of N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide

There total 12 articles about N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1012060-44-4
methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

: 1012056-56-2
N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide

Guidance literature:: methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate; With hydroxylamine; In methanol; at 20 ℃; for 0.5h;

With acetic acid; pH=6 - 7;

Reference yield:

: 886230-75-7
(Ε)-6-nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

: 1012056-56-2
N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C

2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C

2.2: 2 h / 0 °C

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 80 °C

4.1: toluene-4-sulfonic acid / water; methanol / 1 h / 60 °C

5.1: hydroxylamine / methanol / 0.5 h / 20 °C

5.2: pH 6 - 7

With hydrogenchloride; hydroxylamine; iron; ammonium chloride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 119-80-2
2,2'-dithiobenzoic acid

: 1012056-56-2
N-(5-(hydroxycarbamoyl)pentyl)-2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 80 °C

2.1: potassium hydroxide / methanol / 0.17 h / 20 °C

2.2: 1 h

3.1: sodium tetrahydroborate / ethanol / 1 h

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 80 °C

5.1: toluene-4-sulfonic acid / water; methanol / 1 h / 60 °C

6.1: hydroxylamine / methanol / 0.5 h / 20 °C

6.2: pH 6 - 7

With sodium tetrahydroborate; thionyl chloride; hydroxylamine; caesium carbonate; toluene-4-sulfonic acid; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;