methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

Base Information

Chemical Name:methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate
CAS No.:1012060-44-4
Molecular Formula:C₂₈H₂₈N₄O₃S
Molecular Weight:500.621
Hs Code.:

Synonyms:methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

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Chemical Property of methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

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Technology Process of methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

There total 11 articles about methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1012060-43-3
methyl 6-(2-(1-(tetrahydro-2H-pyran-2-yl)-3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

: 1012060-44-4
methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; water; at 60 ℃; for 1h;

Reference yield:

: 886230-75-7
(Ε)-6-nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

: 1012060-44-4
methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C

2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C

2.2: 2 h / 0 °C

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 80 °C

4.1: toluene-4-sulfonic acid / water; methanol / 1 h / 60 °C

With hydrogenchloride; iron; ammonium chloride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 119-80-2
2,2'-dithiobenzoic acid

: 1012060-44-4
methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 80 °C

2.1: potassium hydroxide / methanol / 0.17 h / 20 °C

2.2: 1 h

3.1: sodium tetrahydroborate / ethanol / 1 h

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 80 °C

5.1: toluene-4-sulfonic acid / water; methanol / 1 h / 60 °C

With sodium tetrahydroborate; thionyl chloride; caesium carbonate; toluene-4-sulfonic acid; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;