tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate

Base Information

Chemical Name:tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate
CAS No.:130628-34-1
Molecular Formula:C₃₉H₆₅NO₄Si₃
Molecular Weight:696.206
Hs Code.:

Synonyms:tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate

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Technology Process of tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate

There total 4 articles about tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 130628-33-0
6-[5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-indol-1-yl]-hexanoic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 130628-34-1
tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 35 ℃; for 10h;
DOI:10.1002/ardp.19903230804

Reference yield:

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 130628-34-1
tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH (80 percent) / 1.) DMF, 45 min, 2.a) 0 deg C, b.) 4 h, room temperature

2: BBr₃ / CH₂Cl₂ / 1.) 30 min, 0 deg C, 2.) 2 h, room temperature

3: 43 percent / imidazole / dimethylformamide / 10 h / 35 °C

With 1H-imidazole; boron tribromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19903230804

Reference yield:

: 91444-18-7
5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole

: 130628-34-1
tert-Butyldimethylsilyl 6-<5-(tert-butyldimethylsiloxy)-2-(4-(tert-butyldimethylsiloxy)phenyl)-3-methylindol-1-yl>hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH (80 percent) / 1.) DMF, 45 min, 2.a) 0 deg C, b.) 4 h, room temperature

2: BBr₃ / CH₂Cl₂ / 1.) 30 min, 0 deg C, 2.) 2 h, room temperature

3: 43 percent / imidazole / dimethylformamide / 10 h / 35 °C

With 1H-imidazole; boron tribromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19903230804