dimethyl phosphorobromidate

Base Information

• Chemical Name: dimethyl phosphorobromidate
• CAS No.: 24167-74-6
• Molecular Formula: C₂H₆BrO₃P
• Molecular Weight: 188.946
• Mol file: 24167-74-6.mol

Synonyms:dimethyl phosphorobromidate

Chemical Property of dimethyl phosphorobromidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl phosphorobromidate

There total 2 articles about dimethyl phosphorobromidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

trimethyl phosphite (512-56-1) + 1,4-bis(dibromomethyl)benzene (1592-31-0) → dimethyl phosphorobromidate (24167-74-6) + 4-(dibromomethyl)benzenecarbaldehyde + terephthalaldehyde, (623-27-8)

Guidance literature:

at 180 ℃; for 5.5h;

DOI:10.1016/j.tetlet.2015.12.005

Reference yield:

methyl phosphite (96-36-6,868-85-9) → dimethyl phosphorobromidate (24167-74-6)

Guidance literature:

With tetrachloromethane; N-Bromosuccinimide;

Reference yield: 85.0%

pyridine (110-86-1) + dimethyl phosphorobromidate (24167-74-6) + 5'-O-monomethoxytritylthymidine (42926-80-7,52474-36-9,124680-51-9,132970-00-4) → Phosphoric acid (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester dimethyl ester (72718-36-6) + Phosphoric acid (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester; compound with pyridine (76512-81-7)

Guidance literature:

In benzene; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)71487-0

upstream raw materials:

methyl phosphite

trimethyl phosphite

1,4-bis(dibromomethyl)benzene

Downstream raw materials:

dimethyl N-phenyl-phosphoramidate

Phosphoric acid (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester dimethyl ester

Phosphoric acid (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester; compound with pyridine

dimethyl N-<4-<(benzyloxy)carboxamido>-3-methoxyphenyl>phosphoramidate