methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate

Base Information

• Chemical Name: methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate
• CAS No.: 695186-53-9
• Molecular Formula: C₁₆H₁₃FN₂O₃
• Molecular Weight: 300.289
• Mol file: 695186-53-9.mol

Synonyms:methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate

Chemical Property of methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate

There total 5 articles about methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl [2-(3-fluoro-4-nitrophenyl)benzooxazol-5-yl] acetate (695186-54-0) → methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate (695186-53-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 5h;

DOI:10.1080/00397910902994186

Reference yield:

methyl (4-hydroxy-3-nitrophenyl)acetate (61873-93-6) → methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate (695186-53-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / H₂ / Pd/C / ethyl acetate

2: tetrahydrofuran

3: TsOH / toluene / Heating

4: Zn; AcOH / ethanol

With hydrogen; toluene-4-sulfonic acid; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; toluene;

DOI:10.1016/j.bmcl.2005.03.014

Reference yield:

methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate (695186-52-8) → methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate (695186-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH / toluene / Heating

2: Zn; AcOH / ethanol

With toluene-4-sulfonic acid; acetic acid; zinc; In ethanol; toluene;

DOI:10.1016/j.bmcl.2005.03.014

upstream raw materials:

methyl [2-(3-fluoro-4-nitrophenyl)benzooxazol-5-yl] acetate

methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate

methyl (4-hydroxy-3-nitrophenyl)acetate

methyl (3-amino-4-hydroxyphenyl)acetate