2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid

Base Information

Chemical Name:2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
CAS No.:853929-59-6
Molecular Formula:C₂₄H₁₆BrFN₂O₄
Molecular Weight:495.304
Hs Code.:
Mol file:853929-59-6.mol

Synonyms:W-9 hydrochloride;

Suppliers and Price of 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
OGT 2115
1mg
$ 305.00

TRC
OGT2115
10mg
$ 340.00

Tocris
OGT2115 ≥97%(HPLC)
1
$ 76.00

Tocris
OGT2115 ≥97%(HPLC)
10
$ 163.00

ApexBio Technology
OGT2115
10mg
$ 234.00

ApexBio Technology
OGT2115
1mg
$ 108.00

Total 7 raw suppliers

Chemical Property of 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid

Chemical Property:

Vapor Pressure:9.39E-20mmHg at 25°C
PSA：92.43000
LogP:5.74840
Storage Temp.:Store at RT

Purity/Quality:

97% ^*data from raw suppliers

OGT 2115 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses OGT 2115 is an antiangiogenic heparanase inhibiting compound.

Technology Process of 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid

There total 8 articles about 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.3%

: methyl (2-{4-[(E)-3-(4-bromo-phenyl)acryloylamino]-3-fluorophenyl}benzooxazol-5-yl) acetate

: 853929-59-6
(2-{4-[(E)-3-(4-bromophenyl)acryloylamino]-3-fluorophenyl}benzooxazol-5-yl) acetic acid

Guidance literature:: methyl (2-{4-[(E)-3-(4-bromo-phenyl)acryloylamino]-3-fluorophenyl}benzooxazol-5-yl) acetate; With lithium hydroxide monohydrate; In N,N-dimethyl-formamide; at 20 ℃;

With formic acid; In methanol;
DOI:10.1080/00397910902994186

Reference yield:

: 10463-20-4
4-hydroxy-3-nitrophenylacetic acid

: 853929-59-6
(2-{4-[(E)-3-(4-bromophenyl)acryloylamino]-3-fluorophenyl}benzooxazol-5-yl) acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / HCl / Heating

2: 92 percent / H₂ / Pd/C / ethyl acetate

3: tetrahydrofuran

4: TsOH / toluene / Heating

5: Zn; AcOH / ethanol

6: Et₃N / tetrahydrofuran

7: aq. LiOH / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2005.03.014

Reference yield:

: 61873-93-6
methyl (4-hydroxy-3-nitrophenyl)acetate

: 853929-59-6
(2-{4-[(E)-3-(4-bromophenyl)acryloylamino]-3-fluorophenyl}benzooxazol-5-yl) acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / H₂ / Pd/C / ethyl acetate

2: tetrahydrofuran

3: TsOH / toluene / Heating

4: Zn; AcOH / ethanol

5: Et₃N / tetrahydrofuran

6: aq. LiOH / tetrahydrofuran

With lithium hydroxide; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2005.03.014