methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate

Base Information

• Chemical Name: methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate
• CAS No.: 695186-52-8
• Molecular Formula: C₁₆H₁₃FN₂O₆
• Molecular Weight: 348.287
• Mol file: 695186-52-8.mol

Synonyms:methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate

Chemical Property of methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate

There total 3 articles about methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (4-hydroxy-3-nitrophenyl)acetate (61873-93-6) → methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate (695186-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂ / Pd/C / ethyl acetate

2: tetrahydrofuran

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/j.bmcl.2005.03.014

Reference yield:

3-fluoro-4-nitrobenzoyl chloride (157665-51-5) + methyl (3-amino-4-hydroxyphenyl)acetate (78587-72-1) → methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate (695186-52-8)

Guidance literature:

In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.03.014

Reference yield:

→ methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate (695186-52-8)

Guidance literature:

upstream raw materials:

3-fluoro-4-nitrobenzoyl chloride

methyl (3-amino-4-hydroxyphenyl)acetate

methyl (4-hydroxy-3-nitrophenyl)acetate

Downstream raw materials:

(2-{4-[(E)-3-(4-bromophenyl)acryloylamino]-3-fluorophenyl}benzooxazol-5-yl) acetic acid