2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester

Base Information

Chemical Name:2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester
CAS No.:1315469-26-1
Molecular Formula:C₂₆H₂₃Cl₂N₃O₄
Molecular Weight:512.392
Hs Code.:

Synonyms:2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester

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Chemical Property of 2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester

Chemical Property:

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Technology Process of 2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester

There total 11 articles about 2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.3%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1315469-25-0
[4-(4-bromo-2,5-dichloro-phenoxy)-6-methyl-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-methanone

: 1315469-26-1
2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester

Guidance literature:: With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethyl acetate; at 100 ℃; under 67506.8 Torr;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1315469-26-1
2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 19 h / 20 - 30 °C

2: triethylamine / dichloromethane / 72 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 900.09 Torr

4: triphenylphosphine / N,N-dimethyl-formamide / 4 h / 135 °C

5: borane-THF / tetrahydrofuran / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

7: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 100 °C / 67506.8 Torr

With borane-THF; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1940-42-7,79151-08-9
4-bromo-2,5-dichlorophenol

: 1315469-26-1
2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tetrakis(actonitrile)copper(I) hexafluorophosphate / o-xylene / 20 h / 120 °C

2: water; lithium hydrochloride monohydrate / 1,4-dioxane / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

4: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 100 °C / 67506.8 Torr

With lithium hydrochloride monohydrate; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrakis(actonitrile)copper(I) hexafluorophosphate; In 1,4-dioxane; o-xylene; ethyl acetate; N,N-dimethyl-formamide;