tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

Base Information

• Chemical Name: tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate
• CAS No.: 1312690-48-4
• Molecular Formula: C₃₃H₄₂N₆O₅
• Molecular Weight: 602.734
• Mol file: 1312690-48-4.mol

Synonyms:tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

Chemical Property of tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

There total 7 articles about tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dimethoxybenzylamine (20781-20-8) + methyl 2-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate (1312690-47-3) → tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate (1312690-48-4)

Guidance literature:

methyl 2-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate; With selenium(IV) oxide; In 1,4-dioxane; at 100 ℃; for 24h;

2,4-Dimethoxybenzylamine; In methanol; at 20 ℃; for 0.166667h;

With methanol; sodium cyanoborohydride; at 20 - 50 ℃; for 22h;

Reference yield:

4-methyl-2,6-dioxo-3H-pyrimidine-5-carboxylic acid methyl ester (869891-41-8) → tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate (1312690-48-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trichlorophosphate / N,N-dimethyl-aniline / 6 h / 105 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / Reflux

3.1: triethylamine / ISOPROPYLAMIDE / 4 h / 90 °C

4.1: selenium(IV) oxide / 1,4-dioxane / 24 h / 100 °C

4.2: 0.17 h / 20 °C

4.3: 22 h / 20 - 50 °C

With selenium(IV) oxide; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; N,N-dimethyl-aniline; In 1,4-dioxane; ISOPROPYLAMIDE; acetonitrile;

Reference yield:

methyl 2-chloro-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate (1312690-45-1) → tert-butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate (1312690-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / ISOPROPYLAMIDE / 4 h / 90 °C

2.1: selenium(IV) oxide / 1,4-dioxane / 24 h / 100 °C

2.2: 0.17 h / 20 °C

2.3: 22 h / 20 - 50 °C

With selenium(IV) oxide; triethylamine; In 1,4-dioxane; ISOPROPYLAMIDE;

upstream raw materials:

2,4-Dimethoxybenzylamine

methyl 2-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate

4-methyl-2,6-dioxo-3H-pyrimidine-5-carboxylic acid methyl ester

2,4-dichloro-6-methyl-pyrimidine-5-carboxylic acid methyl ester

Downstream raw materials:

2-((1R,2S)-2-aminocyclohexylamino)-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one