methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

Base Information

Chemical Name:methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate
CAS No.:1247072-06-5
Molecular Formula:C₂₂H₂₇NO₃Si
Molecular Weight:381.547
Hs Code.:

Synonyms:methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

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Chemical Property of methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

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Technology Process of methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

There total 3 articles about methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1247072-04-3
methyl 1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 1247072-07-6
methyl 3-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

: 1247072-06-5
methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

Guidance literature:: With silver(I) acetate; palladium diacetate; Trimethylacetic acid; at 120 ℃; for 3h; regioselective reaction; Microwave irradiation;
DOI:10.1021/ja107159b

Reference yield:

: 50820-65-0
indole-6-carboxylic acid methyl ester

: 1247072-07-6
methyl 3-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

: 1247072-06-5
methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h / 0 °C

2: silver(I) acetate; palladium diacetate; trimethylpyruvic acid / 3 h / 120 °C / Microwave irradiation

With silver(I) acetate; palladium diacetate; trimethylpyruvic acid; potassium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1039/c1cc10755k

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1247072-07-6
methyl 3-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

: 1247072-06-5
methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h / 0 °C

2: silver(I) acetate; palladium diacetate; trimethylpyruvic acid / 3 h / 120 °C / Microwave irradiation

With silver(I) acetate; palladium diacetate; trimethylpyruvic acid; potassium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1039/c1cc10755k