methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate

Base Information

Chemical Name:methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate
CAS No.:1304126-86-0
Molecular Formula:C₂₈H₃₁NO₄SSi
Molecular Weight:505.71
Hs Code.:

Synonyms:methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate

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Chemical Property of methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate

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Technology Process of methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate

There total 6 articles about methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₄ClNO₂Si

: 58414-52-1
thiophen-3-yl-acetic acid methyl ester

: 1304126-86-0
methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2.25h;
DOI:10.1039/c1cc10755k

Reference yield:

: 1304126-85-9
2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carboxylic acid

: 1304126-86-0
methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 2 h / 20 °C

2: n-butyllithium / tetrahydrofuran / 2.25 h / -78 °C

With n-butyllithium; oxalyl dichloride; In tetrahydrofuran; dichloromethane; 2: Friedel Crafts acylation;
DOI:10.1039/c1cc10755k

Reference yield:

: 1247072-06-5
methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate

: 1304126-86-0
methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / dimethyl sulfoxide / 2 h / 20 °C

2: oxalyl dichloride / dichloromethane / 2 h / 20 °C

3: n-butyllithium / tetrahydrofuran / 2.25 h / -78 °C

With n-butyllithium; oxalyl dichloride; water; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 3: Friedel Crafts acylation;
DOI:10.1039/c1cc10755k