4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

Base Information

Chemical Name:4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide
CAS No.:1261576-77-5
Molecular Formula:C₂₃H₁₉Cl₂NO₃S₂
Molecular Weight:492.447
Hs Code.:

Synonyms:4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

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Technology Process of 4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

There total 2 articles about 4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1261576-75-3
4,5-dichloro-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

: 2746-25-0
p-Methoxybenzyl bromide

: 1261576-77-5
4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

Guidance literature:: 4,5-dichloro-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

p-Methoxybenzyl bromide; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2010.09.028

Reference yield:

: 118-31-0
(naphth-1-yl)methylamine

: 1261576-77-5
4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 94.0%

: 198627-86-0
1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate

: 1261576-77-5
4,5-dichloro-N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide

: 1261576-78-6
tert-butyl 4-(3-(3-chloro-5-(N-(4-methoxybenzyl)-N-(naphthalen-1-ylmethyl)sulfamoyl)thiophen-2-yloxy)phenyl)piperazine-1-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 0.416667h; Sealed tube; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.tet.2010.09.028