diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate

Base Information

Chemical Name:diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate
CAS No.:1416159-60-8
Molecular Formula:C₂₇H₃₅N₇O₇
Molecular Weight:569.618
Hs Code.:

Synonyms:diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate

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Chemical Property of diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate

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Technology Process of diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate

There total 7 articles about diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 64-18-6
formic acid

: 1416159-57-3
diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate

: 1416159-60-8
diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate

Guidance literature:: at 60 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.09.027

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 1416159-60-8
diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl acetamide / 48 h / 20 °C

2: acetic acid / 2 h / 20 °C

3: platinum(IV) oxide; trifluoroacetic acid; hydrogen / 72 h / 20 °C / 2250.23 Torr

4: 2 h / 60 °C

With platinum(IV) oxide; hydrogen; trifluoroacetic acid; In N,N-dimethyl acetamide; acetic acid;
DOI:10.1016/j.ejmech.2012.09.027

Reference yield:

: 76807-54-0
6-(Acetoxymethyl)-2,4-dioxopyrido<3,2-d>pyrimidine

: 1416159-60-8
diethyl N-[4-[2-(2,4-diamino-5-formyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl methyl)acetylamino]benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: trichlorophosphate; triethylamine / Reflux

2: ammonia / methanol / 150 °C / Sealed tube

3: phosphorus tribromide

4: N,N-dimethyl acetamide / 48 h / 20 °C

5: acetic acid / 2 h / 20 °C

6: platinum(IV) oxide; trifluoroacetic acid; hydrogen / 72 h / 20 °C / 2250.23 Torr

7: 2 h / 60 °C

With platinum(IV) oxide; ammonia; hydrogen; phosphorus tribromide; triethylamine; trifluoroacetic acid; trichlorophosphate; In methanol; N,N-dimethyl acetamide; acetic acid;
DOI:10.1016/j.ejmech.2012.09.027