thymidine-3'-O-p-chlorophenyl phosphoranisidate

Base Information

Chemical Name:thymidine-3'-O-p-chlorophenyl phosphoranisidate
CAS No.:81087-25-4
Molecular Formula:C₂₃H₂₅ClN₃O₈P
Molecular Weight:537.894
Hs Code.:

Synonyms:thymidine-3'-O-p-chlorophenyl phosphoranisidate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of thymidine-3'-O-p-chlorophenyl phosphoranisidate

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Technology Process of thymidine-3'-O-p-chlorophenyl phosphoranisidate

There total 4 articles about thymidine-3'-O-p-chlorophenyl phosphoranisidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81087-39-0
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

: 81087-25-4
thymidine-3'-O-p-chlorophenyl phosphoranisidate

Guidance literature:: With benzenesulfonic acid; In methanol; dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1248/cpb.29.3440

Reference yield:

: 104-94-9
4-methoxy-aniline

: 81087-25-4
thymidine-3'-O-p-chlorophenyl phosphoranisidate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / diethyl ether; benzene / 6 h / Ambient temperature

2: 98 percent / 1-methyl imidazole / dioxane / 2 h / 25 °C

3: 2 percent benzene-sulfonic acid / CH₂Cl₂; methanol / 0.25 h / 0 °C

With 1-methyl-1H-imidazole; benzenesulfonic acid; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1248/cpb.29.3440

Reference yield:

: 81087-19-6
p-chlorophenyl N-(p-methoxyphenyl)chlorophosphoramidate

: 81087-25-4
thymidine-3'-O-p-chlorophenyl phosphoranisidate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 1-methyl imidazole / dioxane / 2 h / 25 °C

2: 2 percent benzene-sulfonic acid / CH₂Cl₂; methanol / 0.25 h / 0 °C

With 1-methyl-1H-imidazole; benzenesulfonic acid; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1248/cpb.29.3440